There are currently 402 studies in the GENERA database.

Advanced Search

General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
  • China


  • no effect
Safety for consumption
  • no effect

Long-term toxicity study on transgenic rice with Cry1Ac and sck genes

Zhang, M; Zhuo, Q; Tian, Y; Piao, J; Yang, X
Food and Chemical Toxicology. 2014 January. 63(1):76-83

Link to full text (journal may charge for access)

PMID: 24200857 DOI: 10.1016/j.fct.2013.10.035 ISSN: 0278-6915


In the present work, we evaluated the chronic effects of the transgenic insect-resistant rice carrying Cry1Ac and sck genes on Sprague-Dawley (SD) rats through a 78-week feeding study. Based on the gender and weight, 180 SD rats were randomly and evenly assigned into three groups. GM rice and non-GM rice were separately formulated into diets at high levels. AIN-93 diet was used as a nutritional control. Body weight, food consumption, hematology and serum chemistry were monitored regularly. Rats were sacrificed for organ weight measurement and pathological examination at 52weeks and 78weeks. Body weight, food consumption, mortality rates, tumor incidences and pathological findings showed no significant difference among the three groups. Although certain differences in some hematology, serum chemistry parameters and relative organ weights were observed between GM rice group and control groups, they were not considered as treatment-related. Taken together, long-term intake of transgenic rice carrying Cry1Ac and sck genes at a high level exerts no unintended adverse effects on rats.


Transgenic rice; Cry1Ac; sck Genes; Chronic toxicity; Feeding study


Funding source
  • Key Program of Transgenic Plant Breeding
Funding country
  • China
Funding type
  • government

Links to outside analysis of this resource

Please contact us if you know of an independent summary or analysis of this resource.

Cite this study


Zhang, M, Q Zhuo, Y Tian, J Piao, X Yang. "Long-term toxicity study on transgenic rice with Cry1Ac and sck genes." Food and Chemical Toxicology 63.1 (2014): 76-83. Web. 5 Dec. 2023.


Zhang, M., Zhuo, Q., Tian, Y., Piao, J., & Yang, X. (2014). Long-term toxicity study on transgenic rice with Cry1Ac and sck genes. Food and Chemical Toxicology, 63(1), 76-83. doi:10.1016/j.fct.2013.10.035

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.