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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
  • China


Safety for consumption
  • no effect

Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement Open Access

Yuan, Y; Xu, W; He, X; Liu, H; Cao, S; Qi, X; Huang, K; Luo, Y
Scientific Reports. 2013 June. 3(1962

Link to full text (open access, freely available)

PMID: 23752350 DOI: 10.1038/srep01962 ISSN: 2045-2322


Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effects on human health. We constructed an improved safety assessment animal model using a basic subchronic toxicity experiment, measuring a range of parameters including microflora composition, intestinal permeability, epithelial structure, fecal enzymes, bacterial activity, and intestinal immunity. Significant differences were found between rice-fed groups and AIN93G-fed control groups in several parameters, whereas no differences were observed between genetically modified and non-genetically modified groups. No adverse effects were found on GI health resulting from genetically modified T2A-1 rice. In conclusion, this study may offer a systematic safety assessment model for GM material with respect to the effects on GI health.


Mucosal immunology; Microbial genetics; Plant biotechnology; Risk factors; feeding trial; Cry2a


Funding source
  • Genetically Modified Organisms Breeding Major Projects of PR China
Funding country
  • China
Funding type
  • government

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Cite this study


Yuan, Y, W Xu, X He, H Liu, S Cao, X Qi, K Huang, Y Luo. "Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement." Scientific Reports 3. (2013): 1962. Web. 5 Dec. 2023.


Yuan, Y., Xu, W., He, X., Liu, H., Cao, S., Qi, X., Huang, K., & Luo, Y. (2013). Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement. Scientific Reports, 3(), 1962. doi:10.1038/srep01962

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