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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
  • China


  • no effect
Safety for consumption
  • no effect

Safety assessment of Cry1Ab/Ac fusion protein

Xu, W; Cao, S; He, X; Luo, Y; Guo, X; Yuan, Y; Huang, K
Food and Chemical Toxicology. 2009 July. 47(7):1459–1465

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PMID: 19341779 DOI: 10.1016/j.fct.2009.03.029 ISSN: 0278-6915


Cry1ab/ac gene was fused by both the cry1ab gene (GenBank Accession No. X54939) and the cry1ac gene (GenBank Accession No. Y09787), which was widely used in genetically modified (GM) rice, cotton, maize and so on. In order to support the safety assessment of GM food or feed products containing Cry1Ab/Ac protein, sufficient quantities of Cry1Ab/Ac protein were produced in Escherichia coli for in vitro evaluation and animal studies. The Cry1Ab/Ac protein does not possess the characteristics associated with food toxins or allergens, i.e., it has no sequence homology with any known allergens or toxins, and no N-glycosylation sites, can be rapidly degraded in gastric and intestinal fluids, and is devoid of adverse effects in mice by gavage at a high dose level of 5g (Cry1Ab/Ac protein)/kg body weight. In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the Cry1Ab/Ac protein in human food or animal feed.


Cry1Ab/Ac fusion protein; Oral acute study; Safety assessment; GMO


Funding source
  • Ministry of Science and Technology
  • Ministry of Agriculture
Funding country
  • China
Funding type
  • government

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Cite this study


Xu, W, S Cao, X He, Y Luo, X Guo, Y Yuan, K Huang. "Safety assessment of Cry1Ab/Ac fusion protein." Food and Chemical Toxicology 47.7 (2009): 1459–1465. Web. 5 Dec. 2023.


Xu, W., Cao, S., He, X., Luo, Y., Guo, X., Yuan, Y., & Huang, K. (2009). Safety assessment of Cry1Ab/Ac fusion protein. Food and Chemical Toxicology, 47(7), 1459–1465. doi:10.1016/j.fct.2009.03.029

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