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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
  • China


  • no effect
Safety for consumption
  • no effect

Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats

Wang, EH; Yu, Z; Hu, J; Xu, HB
Food and Chemical Toxicology. 2013 December. 62(390–396

Link to full text (journal may charge for access)

PMID: 24012644 DOI: 10.1016/j.fct.2013.08.032 ISSN: 0278-6915


Rice is a staple food crop; however, the threat of pests leads to a serious decline in its output and quality. The CryAb/CryAc gene, encodes a synthetic fusion Bacillus thuringiensis (Bt) crystal protein, was introduced into rice MingHui63 to produce insect-resistant rice TT51. This study was undertaken to investigate potential unintended effects of TT51 on the reproductive system in male rats. Male rats were treated with diets containing 60% of either TT51 or MingHui63 by weight, nutritionally balanced to an AIN93G diet, for 90days. An additional negative control group of rats were fed with a rice-based AIN93G diet. Body weights, food intake, hematology, serum chemistry, serum hormone levels, sperm parameters and relative organ/body weights were measured, and gross as well as microscopic pathology were examined. No diet-related significant differences in the values of response variables were observed between rats that were fed with diet containing transgenic TT51, MingHui63 and the control in this 90-day feeding study. In addition, necropsy and histopathology examination indicated no treatment-related changes. The results from the present study indicated that TT51 does not appear to exert any effect on the reproductive system in male rats compared with MingHui63 or the control.


Transgenic rice; Bacillus thuringiensis; Reproductive toxicity; Sperm parameter; CryAb/CryAc; TT51


Funding source
  • National Major Special Project for the DEvelopment of Transgenic Organisms
  • Ministry of Science
  • Ministry of Agriculture
Funding country
  • China
Funding type
  • government

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Cite this study


Wang, EH, Z Yu, J Hu, HB Xu. "Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats." Food and Chemical Toxicology 62. (2013): 390–396. Web. 22 Jun. 2024.


Wang, EH., Yu, Z., Hu, J., & Xu, HB. (2013). Effects of 90-day feeding of transgenic Bt rice TT51 on the reproductive system in male rats. Food and Chemical Toxicology, 62(), 390–396. doi:10.1016/j.fct.2013.08.032

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