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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • soybean
GE trait
  • herbicide tolerance


Safety for consumption
  • no effect

Effect of GM and non-GM soybeans on the immune system of BN rats and В10A mice Open Access

Teshima, R; Akiyama, H; Okunuki, H; Sakushima, JI; Goda, Y; Onodera, H; Sawada, JI; Toyoda, M
Shokuhin Eiseigaku Zasshi. 2000 January. 41(3):188-193

Link to full text (open access, freely available)

DOI: 10.3358/shokueishi.41.188


Subchronic animal feeding studies to examine the effect of glyphosate-tolerant soybeans, which contain the bacterial 5-enolpyruvylshikimate-3-phosphate synthase from Agrobacterium sp. strain CP4, on the immune system were conducted with BN rats and B10A mice. The studies were designed to compare the feeding value of a line of genetically modified glyphosate-tolerant soybeans (GM soybeans) to that of closely-related and one-parent same cultivar (non-GM soybeans). Heat-treated soybean meal was incorporated into the diets of the rats and mice at a concentration of 30%. The study duration was 15 weeks. Growth, food intake and weights of the liver and the spleen were compared between animals fed the non-GM and GM lines. The histopathology of the thymus, liver, spleen, mesenteric lymph node, Peyer's patches, and small intestine, and the production of soybean-specific IgE and IgG antibodies in the sera were also compared. Growth, feeding value, and the histopathology of immune-related organs showed no significant differences between animals fed GM and non-GM lines. The production of soybean-specific IgE was not detected in the sera of either group, and the increase in soybean-specific IgG was identical in the GM and non-GM groups. No immunotoxic activity was found in GM-soybean-fed rats or mice.


GM soybeans; CP4-EPSPS; BN rat; B10A mouse; immune system


Funding source
  • Not reported
Funding country
  • Not reported
Funding type
  • Not reported

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Cite this study


Teshima, R, H Akiyama, H Okunuki, JI Sakushima, Y Goda, H Onodera, JI Sawada, M Toyoda. "Effect of GM and non-GM soybeans on the immune system of BN rats and В10A mice." Shokuhin Eiseigaku Zasshi 41.3 (2000): 188-193. Web. 4 Mar. 2024.


Teshima, R., Akiyama, H., Okunuki, H., Sakushima, JI., Goda, Y., Onodera, H., Sawada, JI., & Toyoda, M. (2000). Effect of GM and non-GM soybeans on the immune system of BN rats and В10A mice. Shokuhin Eiseigaku Zasshi, 41(3), 188-193. doi:10.3358/shokueishi.41.188

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