There are currently 402 studies in the GENERA database.

Advanced Search

General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
Country
  • China

Results

Efficacy
  • positive effect
Safety for consumption
  • no effect

A 90-day dietary toxicity study of genetically modified rice T1C-1 expressing Cry1C protein in Sprague Dawley rats Open Access

Tang, X; Han, F; Zhao, K; Xu, Y; Wu, X; Wang, J; Jiang, L; Shi, W
PLOS ONE. 2012 December. 7(12):e52507

Link to full text (open access, freely available)

PMID: 23300690 DOI: 10.1371/journal.pone.0052507 ISSN: 1932-6203

Abstract

In a 90-day study, Sprague Dawley rats were fed transgenic T1C-1 rice expressing Cry1C protein and were compared with rats fed non-transgenic parental rice Minghui 63 and rats fed a basal diet. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. A few of these parameters were found to be significantly different, but were within the normal reference intervals for rats of this breed and age, and were thus not considered to be treatment-related. Following sacrifice, a large number of organs were weighed, and macroscopic and histopathological examinations were performed with no changes reported. The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The results showed no adverse or toxic effects due to T1C-1 rice when tested in this 90-day study.

Keywords

rice; feeding trial; Cry1C; Bt; rat

Funding

Funding source
  • Shanghai Agricultural Science Committee Key Foundation of China
  • Changhai Agricultural Science Key Research Foundation
  • The Public Research Platform Foundation of SSTC
  • National Science & Technology Support Programme
  • Changhai Academy of Agricultural Scie
Funding country
  • China
Funding type
  • government

Links to outside analysis of this resource

Please contact us if you know of an independent summary or analysis of this resource.

Cite this study

MLA

Tang, X, F Han, K Zhao, Y Xu, X Wu, J Wang, L Jiang, W Shi. "A 90-day dietary toxicity study of genetically modified rice T1C-1 expressing Cry1C protein in Sprague Dawley rats." PLOS ONE 7.12 (2012): e52507. Web. 11 Dec. 2018.

APA

Tang, X., Han, F., Zhao, K., Xu, Y., Wu, X., Wang, J., Jiang, L., & Shi, W. (2012). A 90-day dietary toxicity study of genetically modified rice T1C-1 expressing Cry1C protein in Sprague Dawley rats. PLOS ONE, 7(12), e52507. doi:10.1371/journal.pone.0052507

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.