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General Information

Document type
  • Peer-reviewed journal article
GE trait
  • insect resistance
  • herbicide tolerance
  • pharmaceutical
  • quality
Country
  • UK, France

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review Review Article

Snell, C; Bernheim, A; Bergé, JB; Kuntz, M; Pascal, G; Paris, A; Ricroch, AE
Food and Chemical Toxicology. 2012 March-April. 50(4-Mar):1134–1148

Link to full text (journal may charge for access)

PMID: 22155268 DOI: 10.1016/j.fct.2011.11.048

Abstract

The aim of this systematic review was to collect data concerning the effects of diets containing GM maize, potato, soybean, rice, or triticale on animal health. We examined 12 long-term studies (of more than 90 days, up to 2 years in duration) and 12 multigenerational studies (from 2 to 5 generations). We referenced the 90-day studies on GM feed for which long-term or multigenerational study data were available. Many parameters have been examined using biochemical analyses, histological examination of specific organs, hematology and the detection of transgenic DNA. The statistical findings and methods have been considered from each study. Results from all the 24 studies do not suggest any health hazards and, in general, there were no statistically significant differences within parameters observed. However, some small differences were observed, though these fell within the normal variation range of the considered parameter and thus had no biological or toxicological significance. If required, a 90-day feeding study performed in rodents, according to the OECD Test Guideline, is generally considered sufficient in order to evaluate the health effects of GM feed. The studies reviewed present evidence to show that GM plants are nutritionally equivalent to their non-GM counterparts and can be safely used in food and feed.

Keywords

GM plant; Animal feeding trial; Safety and nutritional assessment; Long-term studies; Multigenerational studies; Systematic review

Funding

Funding source
  • French National Center for Scientific Research
  • Ministry of Agriculture, Food and Rural Affairs
  • University Paris-Sud, France
Funding country
  • France
Funding type
  • government

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Cite this study

MLA

Snell, C, A Bernheim, JB Bergé, M Kuntz, G Pascal, A Paris, AE Ricroch. "Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review ." Food and Chemical Toxicology 50.4-Mar (2012): 1134–1148. Web. 11 Dec. 2018.

APA

Snell, C., Bernheim, A., Bergé, JB., Kuntz, M., Pascal, G., Paris, A., & Ricroch, AE. (2012). Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review . Food and Chemical Toxicology, 50(4-Mar), 1134–1148. doi:10.1016/j.fct.2011.11.048

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