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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • maize
GE trait
  • insect resistance
  • herbicide tolerance
  • France
  • Italy
  • New Zealand
  • UK
  • USA


Safety for consumption
  • mixed

How subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals Open Access

Séralini, GE; de Vendômois, JS; Cellier, D; Sultan, C; Buiatti, M; Gallagher, L; Antoniou, M; Dronamraju, KR
International Journal of Biological Sciences. 2009 June. 5(5):438-443

Link to full text (open access, freely available)

PMID: 19584953 DOI: 10.7150/ijbs.5.438 ISSN: 1449-2288


Chronic health effects are increasing in the world such as cancers, hormonal, reproductive, nervous, or immune diseases, even in young people. During regulatory toxicological subchronic tests to prevent these on mammalian health, prior commercialization of chemicals, including pesticides and drugs, or GMOs, some statistically significant findings may be revealed. This discussion is about the need to investigate the relevant criteria to consider those as biologically significant. The sex differences and the non linear dose or time related effects should be considered in contrast to the claims of a Monsanto-supported expert panel about a GMO, the MON 863 Bt maize, but also for pesticides or drugs, in particular to reveal hormone-dependent diseases and first signs of toxicities.


Pesticides; GMO; MON 863; side effects; toxicological tests


Funding source
  • University of Caen
  • University of Rouen
Funding country
  • France
Funding type
  • government

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Cite this study


Séralini, GE, JS de Vendômois, D Cellier, C Sultan, M Buiatti, L Gallagher, M Antoniou, KR Dronamraju. "How subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals." International Journal of Biological Sciences 5.5 (2009): 438-443. Web. 22 Jun. 2024.


Séralini, GE., de Vendômois, JS., Cellier, D., Sultan, C., Buiatti, M., Gallagher, L., Antoniou, M., & Dronamraju, KR. (2009). How subchronic and chronic health effects can be neglected for GMOs, pesticides or chemicals. International Journal of Biological Sciences, 5(5), 438-443. doi:10.7150/ijbs.5.438

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