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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • soybean
GE trait
  • herbicide tolerance
  • Japan


Safety for consumption
  • no effect

A 104-week feeding study of genetically modified soybeans in F344 rats Open Access

Sakamoto, Y; Tada, Y; Fukumori, N; Tayama, K; Ando, H; Takahashi, H; Kubo, Y; Nagasawa, A; Yano, N; Yuzawa, K; Ogata, A
Shokuhin Eiseigaku Zasshi. 2008 August. 49(4):272-82

Link to full text (open access, freely available)

PMID: 18787312 DOI: 10.3358/shokueishi.49.272


A chronic feeding study to evaluate the safety of genetically modified glyphosate-tolerant soybeans (GM soybeans) was conducted using F344 DuCrj rats. The rats were fed diet containing GM soybeans or Non-GM soybeans at the concentration of 30% in basal diet. Non-GM soybeans were a closely related strain to the GM soybeans. These two diets were adjusted to an identical nutrient level. In this study, the influence of GM soybeans in rats was compared with that of the Non-GM soybeans, and furthermore, to assess the effect of soybeans themselves, the groups of rats fed GM and Non-GM soybeans were compared with a group fed commercial diet (CE-2). General conditions were observed daily and body weight and food consumption were recorded. At the termination (104 weeks), animals were subjected to hematology, serum biochemistry, and pathological examinations. There were several differences in animal growth, food intake, organ weights and histological findings between the rats fed the GM and/or Non-GM soybeans and the rats fed CE-2. However, body weight and food intake were similar for the rats fed the GM and Non-GM soybeans. Gross necropsy findings, hematological and serum biochemical parameters, and organ weights showed no meaningful difference between rats fed the GM and Non-GM soybeans. In pathological observation, there was neither an increase in incidence nor any specific type of nonneoplastic or neoplastic lesions in the GM soybeans group in each sex. These results indicate that long-term intake of GM soybeans at the level of 30% in diet has no apparent adverse effect in rats.


rat, genetically modified soybean, 104-week feeding study, toxicity test


Funding source
  • Not reported
Funding country
  • Not reported
Funding type
  • Not reported

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Cite this study


Sakamoto, Y, Y Tada, N Fukumori, K Tayama, H Ando, H Takahashi, Y Kubo, A Nagasawa, N Yano, K Yuzawa, A Ogata. "A 104-week feeding study of genetically modified soybeans in F344 rats." Shokuhin Eiseigaku Zasshi 49.4 (2008): 272-82. Web. 23 Jul. 2024.


Sakamoto, Y., Tada, Y., Fukumori, N., Tayama, K., Ando, H., Takahashi, H., Kubo, Y., Nagasawa, A., Yano, N., Yuzawa, K., & Ogata, A. (2008). A 104-week feeding study of genetically modified soybeans in F344 rats. Shokuhin Eiseigaku Zasshi, 49(4), 272-82. doi:10.3358/shokueishi.49.272

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