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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • soybean
GE trait
  • herbicide tolerance
  • quality
Country
  • China, USA

Results

Efficacy
  • positive effect
Safety for consumption
  • no effect

Subchronic feeding study of stacked trait genetically-modified soybean (3Ø5423 × 40-3-2) in Sprague-Dawley rats

Qi, X; He, X; Luo, Y; Li, S; Zou, S; Cao, S; Tang, M; Delaney, B; Xu, W; Huang, K
Food and Chemical Toxicology. 2012 September. 50(9):3256–3263

Link to full text (journal may charge for access)

PMID: 22771368 DOI: 10.1016/j.fct.2012.06.052

Abstract

The genetically-modified (GM) soybean 3Ø5423 × 40-3-2 expresses siRNA for the fatty acid desaturase-2 enzyme which results in higher concentrations of oleic acid (18:1) relative to linoleic acid (18:2) compared with non-GM soybeans. It also expresses the CP4 EPSPS protein for tolerance to glyphosate. In this study, three different dietary concentrations (7.5%, 15% and 30% wt/wt) of 3Ø5423 × 40-3-2 or non-GM soybeans were fed to Sprague-Dawley rats for 90 days during which in-life nutritional and growth performance variables were evaluated followed by analysis of standard clinical chemistry, hematology and organ variables. Compared with rats fed the non-GM control diet, some statistically significant differences were observed in rats fed the 3Ø5423 × 40-3-2 diet. However the differences were not considered treatment-related and commonly fell within the normal ranges of the control group consuming the commercial diet. These results demonstrated that the GM soybean 3Ø5423 × 40-3-2 is as safe as non-GM soybeans.

Keywords

Stacked genetically-modified; High oleic acid soybean; Rat; Subchronic

Funding

Funding source
  • Genetically Modified Organisms Breeding Major Projects of PR China
Funding country
  • China
Funding type
  • government

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Cite this study

MLA

Qi, X, X He, Y Luo, S Li, S Zou, S Cao, M Tang, B Delaney, W Xu, K Huang. "Subchronic feeding study of stacked trait genetically-modified soybean (3Ø5423 × 40-3-2) in Sprague-Dawley rats." Food and Chemical Toxicology 50.9 (2012): 3256–3263. Web. 11 Dec. 2018.

APA

Qi, X., He, X., Luo, Y., Li, S., Zou, S., Cao, S., Tang, M., Delaney, B., Xu, W., & Huang, K. (2012). Subchronic feeding study of stacked trait genetically-modified soybean (3Ø5423 × 40-3-2) in Sprague-Dawley rats. Food and Chemical Toxicology, 50(9), 3256–3263. doi:10.1016/j.fct.2012.06.052

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.