There are currently 402 studies in the GENERA database.

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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
Country
  • Denmark, Germany, China, UK, India

Results

Equivalence
  • mixed
Safety for consumption
  • mixed

A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA).

Poulsen, M; Kroghsbo, S; Schrøder, M; Wilcks, A; Jacobsen, H; Miller, A; Frenzel, T; Danier, J; Rychlik, M; Shu, Q; Emami, K; Sudhakar, D; Gatehouse, A; Engel, KH; Knudsen, I
Food and Chemical Toxicology. 2007 March. 45(3):350–363

Link to full text (journal may charge for access)

PMID: 17052828 DOI: 10.1016/j.fct.2006.09.002

Abstract

Genetically modified plants expressing insecticidal traits offer a new strategy for crop protection, but at the same time present a challenge in terms of food safety assessment. The present 90-day feeding study was designed to assess the safety of a rice variety expressing the snowdrop Galanthus nivalis lectin (GNA lectin), and forms part of a EU-funded project where the objective has been to develop and validate sensitive and specific methods to assess the safety of genetically modified foods. Male and female Wistar rats were given a purified diet containing either 60% genetically modified or parental rice for 90 days. This corresponds to a mean daily GNA lectin intake of approximately 58 and 67mg/kg body weight for males and females, respectively. Prior to the animal study comprehensive analytical characterization of both rice materials was performed. The chemical analyses showed a number of statistically significant differences, with the majority being within the ranges reported in the literature. In the animal study a range of clinical, biological, immunological, microbiological and pathological parameters were examined. A number of significant differences were seen between groups fed the two diets, but none of them were considered to be adverse. In conclusion, the design of the present animal study did not enable us to conclude on the safety of the GM food. Additional group(s) where the expressed gene products have been spiked to the diet should be included in order to be able to distinguish whether the observed effects were due to the GNA lectin per se or to secondary changes in the GM rice.

Keywords

Genetically modified rice; Safety assessment; Animal study; GNA lectin; SAFOTEST

Funding

Funding source
  • European Commission
Funding country
  • EU
Funding type
  • government

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Cite this study

MLA

Poulsen, M, S Kroghsbo, M Schrøder, A Wilcks, H Jacobsen, A Miller, T Frenzel, J Danier, M Rychlik, Q Shu, K Emami, D Sudhakar, A Gatehouse, KH Engel, I Knudsen. "A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA).." Food and Chemical Toxicology 45.3 (2007): 350–363. Web. 13 Dec. 2018.

APA

Poulsen, M., Kroghsbo, S., Schrøder, M., Wilcks, A., Jacobsen, H., Miller, A., Frenzel, T., Danier, J., Rychlik, M., Shu, Q., Emami, K., Sudhakar, D., Gatehouse, A., Engel, KH., & Knudsen, I. (2007). A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA).. Food and Chemical Toxicology, 45(3), 350–363. doi:10.1016/j.fct.2006.09.002

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