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General Information

Document type
  • Peer-reviewed journal article
Study Type
  • feeding study
GE organism
  • maize
GE trait
  • herbicide tolerance
  • insect resistance
  • USA


  • no effect
Safety for consumption
  • no effect

Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats.

MacKenzie, SA; Lamb, I; Schmidt, J; Deege, L; Morrisey, MJ; Harper, M; Layton, RJ; Prochaska, LM; Sanders, C; Locke, M; Mattsson, JL; Fuentes, A; Delaney, B
Food and Chemical Toxicology. 2007 April. 45(4):551–562

Link to full text (journal may charge for access)

PMID: 17097206 DOI: 10.1016/j.fct.2006.09.016 ISSN: 0278-6915


Maize line 1507, containing event DAS-Ø15Ø7-1 (1507), is a genetically modified (GM) maize plant that expresses the cry1F gene from Bacillus thuringiensis (Bt) sbsp. aizawai and the phosphinothricin-N-acetyltransferase (pat) gene from Streptomyces viridochromogenes throughout the plant including in the grain expression of the Cry1F protein confers in planta resistance to the European corn borer (ECB; Ostrinia nubilalis Hübner: Crambidae) and other lepidopteran pests. Expression of the PAT protein confers tolerance to the herbicidal active ingredient glufosinate-ammonium. The current study evaluated the nutritional performance of rats fed diets containing 1507 maize grain in a subchronic rodent feeding study. The grains in this study, 1507, its near-isogenic control (33P66), and a non-GM commercial hybrid (33J56) contained similar amounts of proximates, amino acids, minerals, anti-nutrients, and secondary metabolites. The subchronic feeding study compared standard toxicology response variables in rats fed diets containing 1507 maize grain with those in rats fed diets containing non-GM maize grains. All diets were prepared according to the specifications of PMI Nutrition International, LLC Certified Rodent LabDiet 5002 (PMI) 5002). Diets were fed ad libitum to Sprague-Dawley rats for approximately 90 days. In-life response variables included indicators of dietary performance and weekly evaluations for clinical signs of toxicity. No toxicologically significant differences were observed in the nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between any pair of treatment groups. These results demonstrate that 1507 maize grain is as safe and as nutritious as non-GM maize grain.


European corn borer; GM food; Subchronic feeding study; Cry1F


Funding source
  • Not reported
Funding country
  • Not reported
Funding type
  • Not reported

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Cite this study


MacKenzie, SA, I Lamb, J Schmidt, L Deege, MJ Morrisey, M Harper, RJ Layton, LM Prochaska, C Sanders, M Locke, JL Mattsson, A Fuentes, B Delaney. "Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats.." Food and Chemical Toxicology 45.4 (2007): 551–562. Web. 22 Jun. 2024.


MacKenzie, SA., Lamb, I., Schmidt, J., Deege, L., Morrisey, MJ., Harper, M., Layton, RJ., Prochaska, LM., Sanders, C., Locke, M., Mattsson, JL., Fuentes, A., & Delaney, B. (2007). Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats.. Food and Chemical Toxicology, 45(4), 551–562. doi:10.1016/j.fct.2006.09.016

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