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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • maize
GE trait
  • herbicide tolerance
Country
  • France
  • Belgium
  • USA

Results

Safety for consumption
  • no effect

Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants

Herouet-Guicheney, C; Rouquié, D; Freyssinet, M; Currier, T; Martone, A; Zhou, J; Bates, EE; Ferullo, JM; Hendrickx, K; Rouan, D
Regulatory Toxicology and Pharmacology. 2009 July. 54(2):143–153

Link to full text (journal may charge for access)

PMID: 19303906 DOI: 10.1016/j.yrtph.2009.03.005

Abstract

Glyphosate tolerance can be conferred by decreasing the herbicide's ability to inhibit the enzyme 5-enol pyruvylshikimate-3-phosphate synthase, which is essential for the biosynthesis of aromatic amino acids in all plants, fungi, and bacteria. Glyphosate tolerance is based upon the expression of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) protein. The 2mEPSPS protein, with a lower binding affinity for glyphosate, is highly resistant to the inhibition by glyphosate and thus allows sufficient enzyme activity for the plants to grow in the presence of herbicides that contain glyphosate. Based on both a review of published literature and experimental studies, the potential safety concerns related to the transgenic 2mEPSPS protein were assessed. The safety evaluation supports that the expressed protein is innocuous. The 2mEPSPS enzyme does not possess any of the properties associated with known toxins or allergens, including a lack of amino acid sequence similarity to known toxins and allergens, a rapid degradation in simulated gastric and intestinal fluids, and no adverse effects in mice after intravenous or oral administration (at 10 or 2000 mg/kg body weight, respectively). In conclusion, there is a reasonable certainty of no harm resulting from the inclusion of the 2mEPSPS protein in human food or in animal feed.

Keywords

2mEPSPS protein; Safety; Transgenic; Genetically modified; Glyphosate tolerance

Funding

Funding source
  • Bayer CropScience
Funding country
  • Germany
Funding type
  • industry: same

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Cite this study

MLA

Herouet-Guicheney, C, D Rouquié, M Freyssinet, T Currier, A Martone, J Zhou, EE Bates, JM Ferullo, K Hendrickx, D Rouan. "Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants." Regulatory Toxicology and Pharmacology 54.2 (2009): 143–153. Web. 24 Sep. 2018.

APA

Herouet-Guicheney, C., Rouquié, D., Freyssinet, M., Currier, T., Martone, A., Zhou, J., Bates, EE., Ferullo, JM., Hendrickx, K., Rouan, D . (2009). Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants. Regulatory Toxicology and Pharmacology, 54(2), 143–153. doi:10.1016/j.yrtph.2009.03.005

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