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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • soybean
GE trait
  • quality
  • USA


  • positive effect
Safety for consumption
  • positive effect

Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods Special circumstances Open Access

Harris, WS
The Journal of Nutrition. 2012 March. 142(3):600S-604S

Link to full text (open access, freely available)

PMID: 22279144 DOI: 10.3945/jn.111.146613 ISSN: 0022-3166


Omega-3 (n-3) fatty acids have been reported to have a variety of cardiovascular and neuropsychiatric benefits. Although obtaining the preformed fatty acids EPA and DHA from their traditional source (fish) is optimal, such an approach may not be realistic for meeting the world's growing demand for (n-3) fatty acids; therefore, a more sustainable and dependable source is needed. Stearidonic acid (SDA) is a metabolic precursor of EPA that can be provided by SDA-enhanced soybean oil. Such a product can provide a sustainable source of (n-3) fatty acids that does not endanger fish stocks. Two clinical trials have demonstrated that SDA-enhanced soybean oil can significantly improve an emerging marker of cardiovascular health, the omega-3 index (RBC EPA+DHA). The increase in the Index seen in these trials was used to estimate the potential clinical benefit of SDA consumption based on prior prospective cohort studies. In this analysis, risk for sudden cardiac death and the rate of cellular aging would both theoretically be reduced. The lower risk for major cardiac events seen in the Japan EPA Lipid Intervention Study (which used EPA supplementation) suggests that raising EPA tissue levels, independent of changes in DHA, can have clinical benefit. Thus, the consumption of foods containing SDA-enhanced soybean oil may be both a practical and sustainable approach to enriching tissues with beneficial (n-3) fatty acids.


omega-3; soybean; clincal trial; fatty acid


Funding source
  • American Society for Nutrition
  • Solae LLC
  • Monsanto
Funding country
  • United States
Funding type
  • NGO: independent
  • industry: same

Publication history

This article was published in a supplement to the Journal of Nutrition, and the publication costs "were defrayed in part by the payment of page charges. This publication must therefore be hereby marked as 'advertisement' in accordance with 18 USC section 1734 solely to indicate this fact."

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Cite this study


Harris, WS. "Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods." The Journal of Nutrition 142.3 (2012): 600S-604S. Web. 23 Jul. 2024.


Harris, WS. (2012). Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods. The Journal of Nutrition, 142(3), 600S-604S. doi:10.3945/jn.111.146613

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.