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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • maize
GE trait
  • agronomic properties
  • USA


  • positive effect
  • mixed
Safety for consumption
  • no effect

Nutritional value of a corn containing a glutamate dehydrogenase gene for growing pigs

Guthrie, TA; Apgar, GA; Griswold, KE; Lindemann, MD; Radcliffe, JS; Jacobson, BN
Journal of Animal Science. 2004 June. 82(6):1693-1698

Link to full text (journal may charge for access)

PMID: 15216996 ISSN: 0021-8812


Eight female PIC Line 42 pigs (initial BW = 47.5 +/- 1.8 kg) were used in a two-period switchback design (n = 4 per treatment per period) to evaluate the nutritional difference between a genetically modified corn and a similar nontransgenic corn. The genetically altered corn (gdhA+) contained a glutamate dehydrogenase gene isolated from Escherichia coli. The non-transgenic corn was the same variety lacking the transgenic cassette, grown at the same two locations. Pigs were surgically fitted with steered ileocecal valve cannulas for collection of ileal digesta. Diets were made up of primarily one of the two corn sources. Dietary AA profiles were adjusted using crystalline AA to match Illinois Ideal Protein Ratios. Pigs were limit-fed at 8% of metabolic body weight (BW0.75) in two equal feedings at 0600 and 1800 daily throughout the experiment. The study consisted of two 15-d periods. Each period consisted of a 7-d acclimation period, a 3-d total collection of feces and urine, two 12-h ileal collections, and a 3-d adjustment period between ileal collections to ensure adequate hydration. Crude protein, leucine, methionine, alanine, aspartic acid, glutamic acid, and tyrosine concentrations were greater (P < 0.05) in the gdhA+ corn than in the nontransgenic variety. The presence of the gene did not alter (P > 0.17) BW gain. Similarly, DM digestibility, fecal N excretion (grams per day), apparent total-tract N digestibility, N balance, net protein utilization, and N retained as percentages of absorbed were not affected (P > or = 0.32) by the gene modification. Apparent ileal AA digestibility values did not differ (P > 0.31) between the two dietary treatments. Results of this study suggest corn that contains the E coli. gene for glutamate dehydrogenase was nutritionally equivalent to the unaltered variety.


Digestibility, Maize, Nutrients, Pigs, Transgenics


Funding source
  • Illinois Corn Marketing Board
  • Illinois Council for Food and Agriculture Research
Funding country
  • United States
Funding type
  • government
  • NGO: same industry aligned

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Cite this study


Guthrie, TA, GA Apgar, KE Griswold, MD Lindemann, JS Radcliffe, BN Jacobson. "Nutritional value of a corn containing a glutamate dehydrogenase gene for growing pigs." Journal of Animal Science 82.6 (2004): 1693-1698 . Web. 24 Apr. 2024.


Guthrie, TA., Apgar, GA., Griswold, KE., Lindemann, MD., Radcliffe, JS., & Jacobson, BN. (2004). Nutritional value of a corn containing a glutamate dehydrogenase gene for growing pigs. Journal of Animal Science, 82(6), 1693-1698 .

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.