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General Information

Document type
  • Peer-reviewed journal article
Study Type
  • feeding study
GE organism
  • maize
GE trait
  • insect resistance
Country
  • Italy

Results

Safety for consumption
  • negative effect

Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice

Finamore, A; Roselli, M; Britti, S; Monastra, G; Ambra, R; Turrini, A; Mengheri, E
Journal of Agricultural and Food Chemistry. 2008 November. 56(23):11533–11539

Link to full text (journal may charge for access)

PMID: 19007233 DOI: 10.1021/jf802059w

Abstract

This study evaluated the gut and peripheral immune response to genetically modified (GM) maize in mice in vulnerable conditions. Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-free maize for 30 and 90 days. The immunophenotype of intestinal intraepithelial, spleen, and blood lymphocytes of control maize fed mice was similar to that of pellet fed mice. As compared to control maize, MON810 maize induced alterations in the percentage of T and B cells and of CD4(+), CD8(+), gammadeltaT, and alphabetaT subpopulations of weaning and old mice fed for 30 or 90 days, respectively, at the gut and peripheral sites. An increase of serum IL-6, IL-13, IL-12p70, and MIP-1beta after MON810 feeding was also found. These results suggest the importance of the gut and peripheral immune response to GM crop ingestion as well as the age of the consumer in the GMO safety evaluation.

Keywords

MON810; transgenic maize; mice; intestinal immune response; lymphocytes subpopulations

Funding

Funding source
  • Italian Ministry of Agriculture and Forestry
Funding country
  • Italy
Funding type
  • government

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Cite this study

MLA

Finamore, A, M Roselli, S Britti, G Monastra, R Ambra, A Turrini, E Mengheri. "Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice." Journal of Agricultural and Food Chemistry 56.23 (2008): 11533–11539. Web. 13 Dec. 2018.

APA

Finamore, A., Roselli, M., Britti, S., Monastra, G., Ambra, R., Turrini, A., & Mengheri, E. (2008). Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice. Journal of Agricultural and Food Chemistry, 56(23), 11533–11539. doi:10.1021/jf802059w

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