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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
  • China


Safety for consumption
  • no effect

Potential allergenicity research of Cry1C protein from genetically modified rice

Cao, S; He, X; Xu, W; Luo, Y; Ran, W; Liang, L; Dai, Y; Huang, K
Regulatory Toxicology and Pharmacology. 2012 July. 63(2):181–187

Link to full text (journal may charge for access)

PMID: 22504668 DOI: 10.1016/j.yrtph.2012.03.017 ISSN: 0273-2300


With the development of genetically modified crops, there has been a growing interest in available approaches to assess the potential allergenicity of novel gene products. We were not sure whether Cry1C could induce allergy. We examined the protein with three other proteins to determine the potential allergenicity of Cry1C protein from genetically modified rice. Female Brown Norway (BN) rats received 0.1 mg peanut agglutinin (PNA), 1mg potato acid phosphatase (PAP), 1mg ovalbumin (OVA) or 5 mg purified Cry1C protein dissolved in 1 mL water by daily gavage for 42 days to test potential allergenicity. Ten days after the last gavage, rats were orally challenged with antigens, and physiologic and immunologic responses were studied. In contrast to sensitization with PNA, PAP and OVA Cry1C protein did not induce antigen-specific IgG2a in BN rats. Cytokine expression, serum IgE and histamine levels and the number of eosinophils and mast cells in the blood of Cry1C group rats were comparable to the control group rats, which were treated with water alone. As Cry1C did not show any allergenicity, we make the following conclusion that the protein could be safety used in rice or other plants.


BN rats; Cry1C protein; Potential allergenicity; Genetically modified crops; allergen


Funding source
  • Ministry of Science and Technology
  • Ministry of Agriculture
Funding country
  • China
Funding type
  • government

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Cite this study


Cao, S, X He, W Xu, Y Luo, W Ran, L Liang, Y Dai, K Huang. "Potential allergenicity research of Cry1C protein from genetically modified rice." Regulatory Toxicology and Pharmacology 63.2 (2012): 181–187. Web. 20 Apr. 2024.


Cao, S., He, X., Xu, W., Luo, Y., Ran, W., Liang, L., Dai, Y., & Huang, K. (2012). Potential allergenicity research of Cry1C protein from genetically modified rice. Regulatory Toxicology and Pharmacology, 63(2), 181–187. doi:10.1016/j.yrtph.2012.03.017

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