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General Information

Document type
  • Peer-reviewed journal article
Study Type
  • Metabonomics
  • feeding study
  • microbiome analysis
GE organism
  • rice
GE trait
  • insect resistance
Events
  • T1c-19
Country
  • China

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

Safety assessment of transgenic Bacillus thuringiensis rice T1c-19 in Sprague-Dawley rats from metabonomics and bacterial profile perspectives Open Access

Cao, S; He, X; Xu, W; Luo, Y; Yuan, Y; Liu, P; Cao, B; Shi, H; Huang, K
IUBMB Life. 2012 March. 64(3):242–250

Link to full text (open access, freely available)

PMID: 22215564 DOI: 10.1002/iub.601 ISSN: 1521-6543

Abstract

(GM) organisms are the most important barriers to their promotion. We aimed to establish a new in vivo evaluation model for genetically modified foods by using metabonomics and bacterial profile approaches. T1c-19 rice flour or its transgenic parent MH63 was used at 70% wt/wt to produce diets that were fed to rats for ∼ 90 days. Urine metabolite changes were detected using (1)H NMR. Denaturing gradient gel electrophoresis and real-time polymerase chain reaction (RT-PCR) were used to detect the bacterial profiles between the two groups. The metabonomics was analyzed for metabolite changes in rat urine, when compared with the non-GM rice group, where rats were fed a GM rice diet. Several metabolites correlated with rat age and sex but not with GM rice diet. Significant biological differences were not identified between the GM rice diet and the non-GM rice diet. The bacteria related to rat urine metabolites were also discussed. The results from metabonomics and bacterial profile analyses were comparable with the results attained using the traditional method. Because metabonomics and bacterial profiling offer noninvasive, dynamic approaches for monitoring food safety, they provide a novel process for assessing the safety of GM foods.

Keywords

safety assessment; metabonomics; bacterial profile; T1c-19 rice; GMO

Funding

Funding source
  • Chinese Ministry of Science and Technology
  • Ministry of Agriculture of China
Funding country
  • China
Funding type
  • government

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Cite this study

MLA

Cao, S, X He, W Xu, Y Luo, Y Yuan, P Liu, B Cao, H Shi, K Huang. "Safety assessment of transgenic Bacillus thuringiensis rice T1c-19 in Sprague-Dawley rats from metabonomics and bacterial profile perspectives." IUBMB Life 64.3 (2012): 242–250. Web. 21 Nov. 2018.

APA

Cao, S., He, X., Xu, W., Luo, Y., Yuan, Y., Liu, P., Cao, B., Shi, H., & Huang, K. (2012). Safety assessment of transgenic Bacillus thuringiensis rice T1c-19 in Sprague-Dawley rats from metabonomics and bacterial profile perspectives. IUBMB Life, 64(3), 242–250. doi:10.1002/iub.601

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