There are currently 402 studies in the GENERA database.

Advanced Search

General Information

Document type
  • Peer-reviewed journal article
Study Type
  • feeding study
  • toxicology
GE organism
  • rice
GE trait
  • insect resistance
Events
  • T2A-1
Country
  • China

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats

Cao, S; Xu, W; Luo, Y; He, X; Yuan, Y; Ran, W; Liang, L; Huang, K
Molecular BioSystems. 2011 May. 7(7):2304-2310

Link to full text (journal may charge for access)

PMID: 21594293 DOI: 10.1039/c1mb05076a ISSN: 1742-2051

Abstract

Rice is one of the most important staple foods in the world. The Cry2A gene was inserted into the rice genome to help the plant combat insects. As the unintended effects of the genetically modified (GM) organisms are the most important barriers to the promotion of GM organisms, we have carried out a useful exploration to establish a new in vivo evaluation model for genetically modified foods by metabonomics methods. In this study, the rats were fed for 90 days with the GM and NON-GM rice diets. The changes in metabolites of the urine were detected using (1)H-NMR. The metabonomics were analyzed to see whether the GM rice can induce the metabolite changes in the rats' urine when compared with the NON-GM rice group. The multivariate analysis and ANOVA were used to determine the differences and the significance of differences respectively, and eventually we concluded that these differences did not have a biological significance. The conclusion of the metabonomics was comparable with that from the traditional method. As a non-invasive and dynamic monitoring method, metabonomics will be a new way of assessing the food safety of GM foods.

Keywords

Bacillus thuringiensis; feeding; metabolomics; rice; Bt

Funding

Funding source
  • Genetically Modified Organisms Breeding Major Projects
  • Ministry of Science and Technology
  • Ministry of Agriculture
Funding country
  • China
Funding type
  • government

Links to outside analysis of this resource

Please contact us if you know of an independent summary or analysis of this resource.

Cite this study

MLA

Cao, S, W Xu, Y Luo, X He, Y Yuan, W Ran, L Liang, K Huang. "Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats." Molecular BioSystems 7.7 (2011): 2304-2310. Web. 24 Sep. 2018.

APA

Cao, S., Xu, W., Luo, Y., He, X., Yuan, Y., Ran, W., Liang, L., & Huang, K. (2011). Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats. Molecular BioSystems, 7(7), 2304-2310. doi:10.1039/c1mb05076a

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.