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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • soybean
GE trait
  • herbicide tolerance
  • Switzerland
  • Portugal


  • no effect
Safety for consumption
  • no effect

A proteomic study to identify soya allergens--the human response to transgenic versus non-transgenic soya samples

Batista, R; Martins, I; Jeno, P; Ricardo, CP; Oliveira, MM
International archives of allergy and immunology. 2007 May. 144(1):29-38

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PMID: 17496424 DOI: 10.1159/000102611 ISSN: 1018-2438


Background: In spite of being among the main foods responsible for allergic reactions worldwide, soybean (Glycine max)-derived products continue to be increasingly widespread in a variety of food products due to their well-documented health benefits. Soybean also continues to be one of the elected target crops for genetic modification. The aim of this study was to characterize the soya proteome and, specifically, IgE-reactive proteins as well as to compare the IgE response in soya-allergic individuals to genetically modified Roundup Ready soya® versus its non-transgenic control. Methods: We performed two-dimensional gel electrophoresis of protein extracts from a 5% genetically modified Roundup Ready flour sample and its non-transgenic control followed by Western blotting with plasma from 5 soya-sensitive individuals. We used peptide tandem mass spectrometry to identify soya proteins (55 protein matches), specifically IgE-binding ones, and to evaluate differences between transgenic and non-transgenic samples. Results: We identified 2 new potential soybean allergens – one is maturation associated and seems to be part of the late embryogenesis abundant proteins group and the other is a cysteine proteinase inhibitor. None of the individuals tested reacted differentially to the transgenic versus non-transgenic samples under study. Conclusion: Soybean endogenous allergen expression does not seem to be altered after genetic modification. Proteomics should be considered a powerful tool for functional characterization of plants and for food safety assessment.


allergy; IgE; Roundup Ready; allergen; proteomics; allergenicity


Funding source
  • Calouste Gulbenkian Foundation
Funding country
  • Portugal
Funding type
  • NGO: independent

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Cite this study


Batista, R, I Martins, P Jeno, CP Ricardo, MM Oliveira. "A proteomic study to identify soya allergens--the human response to transgenic versus non-transgenic soya samples." International archives of allergy and immunology 144.1 (2007): 29-38. Web. 22 Jun. 2024.


Batista, R., Martins, I., Jeno, P., Ricardo, CP., & Oliveira, MM. (2007). A proteomic study to identify soya allergens--the human response to transgenic versus non-transgenic soya samples. International archives of allergy and immunology, 144(1), 29-38. doi:10.1159/000102611

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