There are currently 402 studies in the GENERA database.

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General Information

Document type
  • Peer-reviewed journal article
Study Type
  • allergenicity test
GE organism
  • maize
  • soybean
GE trait
  • herbicide tolerance
  • insect resistance
Country
  • Portugal

Results

Safety for consumption
  • no effect

Lack of detectable allergenicity of transgenic maize and soya samples

Batista, R; Nunes, B; Carmo, M; Cardoso, C; José, HS; de Almeida, AB; Manique, A; Bento, L; Ricardo, CP; Oliveira, MM
Journal of Allergy and Clinical Immunology . 2005 August. 116(2):403–410

Link to full text (journal may charge for access)

PMID: 16083797 DOI: 10.1016/j.jaci.2005.04.014 ISSN: 0091-6749

Abstract

BACKGROUND: The safety issues regarding foods derived from genetically modified (GM) plants are central to their acceptance into the food supply. The potential allergenicity of proteins newly introduced in GM foods is a major safety concern. OBJECTIVE: We sought to monitor, in potentially sensitive human populations, the allergenicity effects of 5 GM materials obtained from sources with no allergenic potential and already under commercialization in the European Union. METHODS: We have performed skin prick tests with protein extracts prepared from transgenic maize (MON810, Bt11, T25, Bt176) and soya (Roundup Ready) samples and from nontransgenic control samples in 2 sensitive groups: children with food and inhalant allergy and individuals with asthma-rhinitis. We have also tested IgE immunoblot reactivity of sera from patients with food allergy to soya (Roundup Ready) and maize (MON810, Bt11, Bt176) samples, as well as to the pure transgenic proteins (CryIA[b] and CP4 5-enolpyruvylshikimate-3-phosphate synthase). RESULTS: None of the individuals undergoing tests reacted differentially to the transgenic and nontransgenic samples under study. None of the volunteers tested presented detectable IgE antibodies against pure transgenic proteins. CONCLUSION: The transgenic products under testing seem to be safe in terms of allergenic potential. We propose postmarket testing as an important screening strategy for putative allergic sensitization to proteins introduced in transgenic plants.

Keywords

Transgenic food; allergenicity; immune response; public health; food safety; recombinant DNA technology

Funding

Funding source
  • Calouste Gulbenkian Foundation
  • Portuguese Health Ministry
Funding country
  • Portugal
Funding type
  • NGO: independent
  • government

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Cite this study

MLA

Batista, R, B Nunes, M Carmo, C Cardoso, HS José, AB de Almeida, A Manique, L Bento, CP Ricardo, MM Oliveira. "Lack of detectable allergenicity of transgenic maize and soya samples ." Journal of Allergy and Clinical Immunology 116.2 (2005): 403–410. Web. 29 Mar. 2024.

APA

Batista, R., Nunes, B., Carmo, M., Cardoso, C., José, HS., de Almeida, AB., Manique, A., Bento, L., Ricardo, CP., & Oliveira, MM. (2005). Lack of detectable allergenicity of transgenic maize and soya samples . Journal of Allergy and Clinical Immunology , 116(2), 403–410. doi:10.1016/j.jaci.2005.04.014

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