• Peer-reviewed journal article

• feeding study

• Maize

• herbicide tolerance

• NK603

• France
• Italy

• mixed

• negative effect

The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats. In females, all treated groups died 2–3 times more than controls, and more rapidly. This difference was vis- ible in 3 male groups fed GMOs. All results were hormone and sex dependent, and the pathological pro- files were comparable. Females developed large mammary tumors almost always more often than and before controls, the pituitary was the second most disabled organ; the sex hormonal balance was mod- ified by GMO and Roundup treatments. In treated males, liver congestions and necrosis were 2.5–5.5 times higher. This pathology was confirmed by optic and transmission electron microscopy. Marked and severe kidney nephropathies were also generally 1.3–2.3 greater. Males presented 4 times more large palpable tumors than controls which occurred up to 600 days earlier. Biochemistry data confirmed very significant kidney chronic deficiencies; for all treatments and both sexes, 76% of the altered parameters were kidney related. These results can be explained by the non linear endocrine-disrupting effects of Roundup, but also by the overexpression of the transgene in the GMO and its metabolic consequences.

• Association Ceres
• Auchan
• Carrefour
• Foundation Charles Leopold Mayer
• French Ministry of Research
• CRIIGEN

• France
• Switzerland

• industry: competing
• NGO: competing industry aligned
• government

• Review by the European Food Safety Authority (EFSA)
• Wikipedia: The Séralini Affair
• Elsevier Announces Article Retraction from Journal Food and Chemical Toxicology
• Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize

MLA

Séralini, Gilles-Eric, Emilie Clair, Robin Mesnage, Steeve Gress, Nicolas Defarge, Manuela Malatesta, Didier Hennequin, Joël Spiroux de Vendômois. "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize." Food and Chemical Toxicology 50.11 (2012): 4221–4231. Web. 18 Apr. 2024.

APA

Séralini, Gilles-Eric., Clair, Emilie., Mesnage, Robin., Gress, Steeve., Defarge, Nicolas., Malatesta, Manuela., Hennequin, Didier., de Vendômois, Joël Spiroux. (2012). Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food and Chemical Toxicology, 50(11), 4221–4231. doi:10.1016/j.fct.2012.08.005

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