There are currently 402 studies in the GENERA database.

Advanced Search

General Information

Document type
  • Peer-reviewed journal article
GE organism
  • maize
GE trait
  • insect resistance
Country
  • Turkey

Results

Safety for consumption
  • mixed

A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation.

Kiliç, A; Akay, MT
Food and Chemical Toxicology. 2008 March. 46(3):1164–1170

Link to full text (journal may charge for access)

PMID: 18191319 DOI: 10.1016/j.fct.2007.11.016 ISSN: 0278-6915

Abstract

For the last ten years, in accordance with the increased use of genetically modified (GM) foods for human and livestock, a large number of feeding studies have been carried out. However, the evidence is still far from proving whether the long-term consumption of GM foods poses a possible danger for human or animal health. Therefore, this study was designed to evaluate the effects of transgenic corn on the rats that were fed through three generations with either GM corn or its conventional counterpart. Tissue samples of stomach, duodenum, liver and kidney were obtained for histopathological examinations. The average diameter of glomeruli, thickness of renal cortex and glomerular volume were calculated and number of affected animals/number of examined animals for liver and kidney histopathology were determined. Amounts of urea, urea nitrogen, creatinine, uric acid, total protein, albumin and globulin were determined; enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyltransferase, creatine kinase and amylase were measured in serum samples. No statistically significant differences were found in relative organ weights of rats within groups but there were some minimal histopathological changes in liver and kidney. Changes in creatinine, total protein and globulin levels were also determined in biochemical analysis.

Keywords

Transgenic Bt corn; Three generation study; Histopathology; Biochemical analysis; Wistar albino rat

Funding

Funding source
  • Not reported
Funding country
  • Not reported
Funding type
  • Not reported

Links to outside analysis of this resource

Please contact us if you know of an independent summary or analysis of this resource.

Cite this study

MLA

Kiliç, A, MT Akay. "A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation.." Food and Chemical Toxicology 46.3 (2008): 1164–1170. Web. 19 Nov. 2017.

APA

Kiliç, A., & Akay, MT. (2008). A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation.. Food and Chemical Toxicology, 46(3), 1164–1170. doi:10.1016/j.fct.2007.11.016

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.