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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • triticale
GE trait
  • herbicide tolerance
Country
  • Poland

Results

Safety for consumption
  • no effect

Micronucleus test and comet assay on mice fed over five generations a diet containing genetically modified triticale Open Access

Jaszczak, K; Kruszewski, M; Baranowski, A; Parada, R; Bartłomiejczyk, T; Zimny, J; Rosochacki, S
Journal of Animal and Feed Sciences . 2008 January. 17(1):100–109

Link to full text (open access, freely available)



Abstract

One of the concerns regarding the common use of genetically modified (GM) feed in animal nutrition is that transgenic sequences may have a negative effect on the organism or (and) its cells. The present report assesses the genotoxic potential effect of a diet containing GM triticale on mice by using micronuclei test and comet assay. One group of mice (C57 Bl/6J strain) were fed continuously over five generations a pelleted diet containing 20% of GM triticale (tolerant to phosphinothricine) grain, while the control group was fed pellets with 20% conventional triticale grain. Ten 91-days-old mice (five females and five males) were randomly selected from each group and each generation for micronuclei test in bone marrow and peripheral blood erythrocytes and the some number of mice was used for comet assay. The results obtained did not reveal any statistically significant differences in the micronuclei frequency nor any other DNA damage between the control and experimental groups of mice in all five generations. Thus, it seems evident that the diet containing GM triticale (with bar transgene) does not induce chromosome damage, nor has it any effect on the formation of DNA breaks or base lesions.

Keywords

GM triticale; multigeneration feeding; erythrocytes; micronucleus test; comet assay; mice

Funding

Funding source
  • State Committee for Scientific Research
Funding country
  • Poland
Funding type
  • government

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Cite this study

MLA

Jaszczak, K, M Kruszewski, A Baranowski, R Parada, T Bartłomiejczyk, J Zimny, S Rosochacki. "Micronucleus test and comet assay on mice fed over five generations a diet containing genetically modified triticale." Journal of Animal and Feed Sciences 17.1 (2008): 100–109. Web. 18 Dec. 2017.

APA

Jaszczak, K., Kruszewski, M., Baranowski, A., Parada, R., Bartłomiejczyk, T., Zimny, J., & Rosochacki, S. (2008). Micronucleus test and comet assay on mice fed over five generations a diet containing genetically modified triticale. Journal of Animal and Feed Sciences , 17(1), 100–109.

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