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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • potato
GE trait
  • quality
Country
  • Japan

Results

Safety for consumption
  • no effect

Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats Open Access

Hashimoto, W; Momma, K; Yoon, HJ; Ozawa, S; Ohkawa, Y; Ishige, T; Kito, M; Utsumi, S; Murata, K
Bioscience, Biotechnology, and Biochemistry. 1999 November. 63(11):1942-1946

Link to full text (open access, freely available)

PMID: 10635558 DOI: 10.1271/bbb.63.1942 ISSN: 0916-8451

Abstract

Feeding studies of transgenic potatoes with native and designed soybean glycinins in rats were done for four weeks. The designed glycinin has four additional methioninyl residues in the middle of the glycinin molecule. Rats were divided into four groups fed (I) only a commercial diet, (II) the diet plus non-transgenic potatoes, (III) the diet plus transgenic potatoes with native glycinin, and (IV) the diet plus transgenic potatoes with designed glycinin. Rats were fed 2,000 mg/kg-weight potatoes every day by oral administration. During the period tested, rats in each group (groups II, III, and IV) grew well without marked differences in appearance, food intake, body weight, or in cumulative body weight gain. No significant differences were also found in blood count, blood composition, and in internal organ weights among the rats after feeding potatoes (groups II, III, and IV) for four weeks. Necropsy at the end of experiment indicated neither pathologic symptoms in all rats tested nor histopathological abnormalities in liver and kidney. Judging from these results, the transgenic potatoes with glycinins are confirmed to have nearly the same nutritional and biochemical characteristics as non-transgenic one.

Keywords

animal feeding study; food safety; transgenic potato; soybean glycinin

Funding

Funding source
  • Bio-oriented Technology Research Advancement Institution of Japan (BRAIN)
Funding country
  • Japan
Funding type
  • government

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Cite this study

MLA

Hashimoto, W, K Momma, HJ Yoon, S Ozawa, Y Ohkawa, T Ishige, M Kito, S Utsumi, K Murata. "Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats ." Bioscience, Biotechnology, and Biochemistry 63.11 (1999): 1942-1946. Web. 25 Sep. 2017.

APA

Hashimoto, W., Momma, K., Yoon, HJ., Ozawa, S., Ohkawa, Y., Ishige, T., Kito, M., Utsumi, S., Murata, K . (1999). Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats . Bioscience, Biotechnology, and Biochemistry, 63(11), 1942-1946. doi:10.1271/bbb.63.1942

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