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General Information

Document type

Peer-reviewed journal article

GE organism

potato

GE trait

insect resistance

Country

Results

Safety for consumption

negative effect

Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine

Ewen, SW; Pusztai, A
Lancet. 1999 October. 345(9187):1353-1354

Link to full text (journal may charge for access)

PMID: 10533866 DOI: 10.1016/S0140-6736(98)05860-7

Abstract

Diets containing genetically modified (GM) potatoes expressing the lectin Galanthus nivalis agglutinin (GNA) had variable effects on different parts of the rat gastrointestinal tract. Some effects, such as the proliferation of the gastric mucosa, were mainly due to the expression of the GNA transgene. However, other parts of the construct or the genetic transformation (or both) could also have contributed to the overall biological effects of the GNA-GM potatoes, particularly on the small intestine and caecum.

Keywords

lectin; feeding study; potato

Funding

Funding source

Scottish Office: Agriculture, Environment, and Fishery Department

Funding country

Funding type

government

Publication history

http://www.ncbi.nlm.nih.gov/pubmed/10533866

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Cite this study

MLA

Ewen, SW, A Pusztai. "Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine." Lancet 345.9187 (1999): 1353-1354. Web. 20 Apr. 2024.

APA

Ewen, SW., & Pusztai, A. (1999). Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet, 345(9187), 1353-1354. doi:10.1016/S0140-6736(98)05860-7

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.