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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • cotton
GE trait
  • insect resistance
Country
  • USA

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats

Dryzga, MD; Yano, BL; Andrus, AK; Mattsson, JL
Food and Chemical Toxicology. 2007 October. 45(10):1994–2004

Link to full text (journal may charge for access)

PMID: 17574718 DOI: 10.1016/j.fct.2007.04.017

Abstract

Meal prepared from Cry1F/Cry1Ac transgenic/genetically modified cottonseed (WIDESTRIKE Insect Protection, hereafter referred to as WIDESTRIKE) was compared to cottonseed meal prepared from four conventionally bred lines of cotton (three commercial non-transgenic line controls (PHY72, PHY78 and 98M-2983), and a near isoline non-transgenic control (PSC355) in a 90-day dietary study to evaluate safety and nutritional equivalence. Diets were formulated with 10% WIDESTRIKE cottonseed meal equivalent to 7,235 mg/kg/day for males and 7,935 mg/kg/day for females. Animals were evaluated by cage-side and hand-held detailed clinical observations, body weight, and feed consumption. Functional tests, motor activity and ophthalmic examinations were conducted pre-exposure and prior to study termination. Standard hematology, clinical chemistry, prothrombin time and urinalysis parameters were evaluated. All rats had a complete necropsy and selected organs were weighed. Histopathologic examinations were performed on all rats fed the diets containing the near isoline non-transgenic control or WIDESTRIKE. Following 90 days of feeding, no adverse effects were observed during the conduct of clinical observations or in any of the parameters measured in this study. This study demonstrated that rodent diets prepared with 10% cottonseed meal from WIDESTRIKE cottonseeds do not produce any untoward effects and are nutritionally equivalent to cottonseed meals prepared from other, non-transgenic cottonseeds.

Keywords

WIDESTRIKE™; Bacillus thuringiensis (B.t.); B.t. Gene; Transgenic; Subchronic toxicity; Rats

Funding

Funding source
  • Dow Agrosciences
Funding country
  • United States
Funding type
  • industry: same

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Cite this study

MLA

Dryzga, MD, BL Yano, AK Andrus, JL Mattsson. "Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats." Food and Chemical Toxicology 45.10 (2007): 1994–2004. Web. 25 Jul. 2017.

APA

Dryzga, MD., Yano, BL., Andrus, AK., & Mattsson, JL. (2007). Evaluation of the safety and nutritional equivalence of a genetically modified cottonseed meal in a 90-day dietary toxicity study in rats. Food and Chemical Toxicology, 45(10), 1994–2004. doi:10.1016/j.fct.2007.04.017

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.