There are currently 402 studies in the GENERA database.

Advanced Search

General Information

Document type
  • Peer-reviewed journal article
GE trait
  • herbicide tolerance
  • insect resistance
Country
  • USA

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

Thirteen week rodent feeding study with grain from molecular stacked trait lepidopteran and coleopteran protected (DP-ØØ4114-3) maize Open Access

Delaney, B; Karaman, S; Roper, J; Hoban, D; Sykes, G; Mukerji, P; Frame, SR
Food and Chemical Toxicology. 2013 March. 53(417-27

Link to full text (open access, freely available)

PMID: 23261672 DOI: 10.1016/j.fct.2012.12.002

Abstract

The results from a subchronic feeding study conducted in Sprague–Dawley rats fed with diets containing grain from 4114 (OECD unique identifier: DP-ØØ4114-3) maize that was untreated (4114) or sprayed in field with glufosinate ammonium (4114GLU) in a design similar to previous studies are reported. The test material, 4114 maize, is a hybrid maize produced by transformation with a DNA construct encoding 4 different transgenic proteins for resistance to lepidopteran pests, coleopteran pests, and tolerance to the herbicidal active ingredient glufosinate ammonium. There were a total of 144 rats divided into 12 groups of 12 rats/sex/group. All experimental diets were formulated by Purina Mills, LLC (St. Louis, MO) in accordance with the standards of Purina Mills Labdiet® Certified Rodent LabDiet® 5002. The incorporation rate of maize grain in all diets was 32% (wt/wt). No biologically significant, treatment related differences in body weight, food consumption, clinical pathology parameters (hematology, blood chemistry, urinalysis, or organ weight) were observed in rats consuming the diets containing 4114 maize grain compared with rats fed conventional maize diets. A number of histologic observations were noted in this study but were background lesions and representative of what would be expected for rats of this age and strain. An independent panel of experts determined certain observations to be spontaneous and not related to the test diet. Accordingly, these results support the conclusion that 4114 maize grain is as safe and nutritious as conventional maize grain.

Keywords

Corn rootworm; European corn borer; Subchronic feeding study; Rat; Biotechnology

Funding

Funding source
  • DuPont Pioneer
Funding country
  • United States
Funding type
  • industry: same

Links to outside analysis of this resource

Please contact us if you know of an independent summary or analysis of this resource.

Cite this study

MLA

Delaney, B, S Karaman, J Roper, D Hoban, G Sykes, P Mukerji, SR Frame. "Thirteen week rodent feeding study with grain from molecular stacked trait lepidopteran and coleopteran protected (DP-ØØ4114-3) maize." Food and Chemical Toxicology 53. (2013): 417-27. Web. 27 Jul. 2017.

APA

Delaney, B., Karaman, S., Roper, J., Hoban, D., Sykes, G., Mukerji, P., & Frame, SR. (2013). Thirteen week rodent feeding study with grain from molecular stacked trait lepidopteran and coleopteran protected (DP-ØØ4114-3) maize. Food and Chemical Toxicology, 53(), 417-27. doi:10.1016/j.fct.2012.12.002

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.