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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • rice
GE trait
  • insect resistance
Country
  • China

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource

Cao, S; He, X; Xu, W; Ran, W; Liang, L; Luo, Y; Yuan, Y; Zhang, N; Zhou, X; Huang, K
Regulatory Toxicology and Pharmacology. 2010 December. 58(3):474–481

Link to full text (journal may charge for access)

PMID: 20801181 DOI: 10.1016/j.yrtph.2010.08.018 ISSN: 0273-2300

Abstract

The Cry1C protein produced in Escherichia coli was used for in vitro evaluation and animal studies to support the safety assessment of GM food or feed products containing the Cry1C protein. The Cry1C protein does not have any sequence homology with known allergens or toxins. Although the Cry1C protein was heat stable it was rapidly degraded in vitro with simulated gastric or intestinal fluids. It did not cause adverse effects in mice as administered by gavage at a high level dosage of 5 g (Cry1C protein)/kg body weight. The mutagenicity of this protein was evaluated according to the national standards of People's Republic of China (PR China) for a new food resource. In mutagenic tests, the Cry1C protein caused<4 micronucleated cells per 1000 cells, <16 sperm abnormalities per 1000 cells and was not associated with any increased mutations in the Ames test. Taken together, these data indicate that the Cry1C protein is not a potential allergen or toxin.

Keywords

Cry1C protein; Oral acute study; Safety assessment; Micronucleus assay; Sperm shape abnormality test; Ames test; GMO

Funding

Funding source
  • Ministry of Science and Technology
  • Ministry of Agriculture
Funding country
  • China
Funding type
  • government

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Cite this study

MLA

Cao, S, X He, W Xu, W Ran, L Liang, Y Luo, Y Yuan, N Zhang, X Zhou, K Huang. "Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource." Regulatory Toxicology and Pharmacology 58.3 (2010): 474–481. Web. 19 Nov. 2017.

APA

Cao, S., He, X., Xu, W., Ran, W., Liang, L., Luo, Y., Yuan, Y., Zhang, N., Zhou, X., & Huang, K. (2010). Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource. Regulatory Toxicology and Pharmacology, 58(3), 474–481. doi:10.1016/j.yrtph.2010.08.018

Please verify citations before use, citations are automatically generated based on information stored within the GENERA database and therefore may or may not be correct.