There are currently 402 studies in the GENERA database.

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General Information

Document type
  • Peer-reviewed journal article
GE organism
  • soybean
GE trait
  • herbicide tolerance
Country
  • USA

Results

Equivalence
  • no effect
Safety for consumption
  • no effect

A generational study of glyphosate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development

Brake, DG; Evenson, DP
Food and Chemical Toxicology . 2004 January. 42(1):29–36

Link to full text (journal may charge for access)

PMID: 14630127 DOI: 10.1016/j.fct.2003.08.003 ISSN: 0278-6915

Abstract

The health safety of transgenic soybeans (glyphosate-tolerant or Roundup Ready) was studied using the mammalian testis (mouse model) as a sensitive biomonitor of potential toxic effects. Pregnant mice were fed a transgenic soybean or a non-transgenic (conventional) diet through gestation and lactation. After weaning, the young male mice were maintained on the respective diets. At 8, 16, 26, 32, 63 and 87 days after birth, three male mice and an adult reference mouse were killed, the testes surgically removed, and the cell populations measured by flow cytometry. Multi-generational studies were conducted in the same manner. The results showed that the transgenic foodstuffs had no effect on macromolecular synthesis or cell growth and differentiation as evidenced by no differences in the percentages of testicular cell populations (haploid, diploid, and tetraploid) between the transgenic soybean-fed mice and those fed the conventional diet. Additionally, there were no differences in litter sizes and body weights of the two groups. It was concluded that the transgenic soybean diet had no negative effect on fetal, postnatal, pubertal or adult testicular development.

Keywords

Glyphosate-tolerant soybeans; Roundup Ready soybeans; Transgenic crops; Testicular cell populations; Flow cytometry; Fetal/pubertal testicular differentiation; multi-generational

Funding

Funding source
  • South Dakota Legislature
Funding country
  • United States
Funding type
  • government

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Cite this study

MLA

Brake, DG, DP Evenson. "A generational study of glyphosate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development ." Food and Chemical Toxicology 42.1 (2004): 29–36. Web. 19 Sep. 2017.

APA

Brake, DG., & Evenson, DP. (2004). A generational study of glyphosate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development . Food and Chemical Toxicology , 42(1), 29–36. doi:10.1016/j.fct.2003.08.003

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